Publications by authors named "A Caruntu"
With the development of 3D bioprinting and the creation of innovative biocompatible materials, several new approaches have brought advantages to patients and surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses and implementing new solutions relies on the ability of engineers and medical teams to identify methods of anchoring 3D-printed prostheses and to reveal the potential influence of bioactive materials on surrounding tissues. In this paper, we described why limb salvage surgery based on 3D bioprinting is a reliable and effective alternative to amputations, and why this approach is considered the new standard in modern medicine.
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- - Somatostatin is a peptide with multifaceted roles as a neurotransmitter and endocrine regulator, primarily exerting inhibitory effects in various tissues, despite its low physiological concentrations.
- - It binds to specific receptors called somatostatin receptors (SSTRs), which differ in tissue distribution and can be altered in conditions like tumors, making them useful as cancer biomarkers and for prognostic insights.
- - The review discusses the five SSTRs, their therapeutic potentials for multiple conditions, including tumors and acromegaly, as well as the potential use of somatostatin antagonists in medical settings.
Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing.
View Article and Find Full Text PDFObesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines.
View Article and Find Full Text PDFOral squamous cell carcinoma (OSCC), the most common type of head and neck cancer, remains a highly challenging cancer to treat, largely due to the late diagnosis in advanced stages of the disease, which occurs in more than half of cases [...
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