For the commercial sector, warehouses are becoming increasingly vital. Constant efforts are in progress to increase the efficiency of these facilities while reducing costs. The inventory part of the goods is a time-consuming task that impacts the company's revenue.
View Article and Find Full Text PDFOne of the most relevant problems related to Unmanned Aerial Vehicle's (UAV) autonomous navigation for industrial inspection is localization or pose estimation relative to significant elements of the environment. This paper analyzes two different approaches in this regard, focusing on its application to unstructured scenarios where objects of considerable size are present, such as a truck, a wind tower, an airplane, a building, etc. The presented methods require a previously developed Computer-Aided Design (CAD) model of the main object to be inspected.
View Article and Find Full Text PDFThe genome resequencing of spontaneous glyphosate-resistant mutants derived from the soybean inoculant E109 allowed identifying genes most likely associated with the uptake (gltL and cya) and metabolism (zigA and betA) of glyphosate, as well as with nitrogen fixation (nifH). Mutations in these genes reduce the lag phase and improve nodulation under glyphosate stress. In addition to providing glyphosate resistance, the amino acid exchange Ser90Ala in NifH increased the citrate synthase activity, growth rate and plant growth-promoting efficiency of E109 in the absence of glyphosate stress, suggesting roles for this site during both the free-living and symbiotic growth stages.
View Article and Find Full Text PDFPurpose: Patients with Fanconi anaemia (FA), a rare DNA repair genetic disease, exhibit chromosome fragility, bone marrow failure, malformations and cancer susceptibility. FA molecular diagnosis is challenging since FA is caused by point mutations and large deletions in 22 genes following three heritability patterns. To optimise FA patients' characterisation, we developed a simplified but effective methodology based on whole exome sequencing (WES) and functional studies.
View Article and Find Full Text PDFAims: The clinical implications of the programmed cell death 1 (PD1)/programmed cell death-ligand 1 (PD-L1) axis in patients with post-transplant lymphoproliferative disorders are largely unknown, and its association with Epstein-Barr virus (EBV) status and PD-L1 copy number alterations (CNAs) has not been thoroughly studied.
Methods And Results: PD1/PD-L1 expression was studied in 50 adult post-transplant lymphoproliferative disorders, and the correlations with PD-L1 CNAs, EBV, clinicopathological features and outcome were evaluated. Thirty-seven (74%) cases were classified as diffuse large B-cell lymphoma (DLBCL), nine (18%) cases were classified as polymorphic, and four (8%) cases were classified as classic Hodgkin lymphoma.