Publications by authors named "A Caroline Mauser"
Despite decades of intense research, glioma remains a disease for which no adequate clinical treatment exists. Given the ongoing therapeutic failures of conventional treatment approaches, nanomedicine may offer alternative options because it can increase the bioavailability of drugs and alter their pharmacokinetics. Here, a new type of synthetic protein nanoparticles (SPNPs) is reported that allow for effective loading and controlled release of the potent cancer drug, paclitaxel (PTX) - a drug that so far has been unsuccessful in glioma treatment due to hydrophobicity, low solubility, and associated delivery challenges.
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- The study examined how data evaluation parameters affect the results of analyzing post-translational modifications in bovine whey protein, specifically α-lactalbumin combined with lactose.
- Adjustments to the protein database and enzyme settings in PEAKS studio software improved peptide identification rates significantly, increasing the total number of detected peptides from 322 to 535.
- Despite challenges in reproducibility, the label-free quantification (LFQ) algorithm proved more effective, enhancing quantified peptides from 75 to 179, while a considerable portion of peptides remained inconsistently detected across samples.
We present a modular strategy to synthesize nanoparticle sensors equipped with dithiomaleimide-based, fluorescent molecular reporters capable of discerning minute changes in interparticle chemical environments based on fluorescence lifetime analysis. Three types of nanoparticles were synthesized with the aid of tailor-made molecular reporters, and it was found that protein nanoparticles exhibited greater sensitivity to changes in the core environment than polymer nanogels and block copolymer micelles. Encapsulation of the hydrophobic small-molecule drug paclitaxel (PTX) in self-reporting protein nanoparticles induced characteristic changes in fluorescence lifetime profiles, detected via time-resolved fluorescence spectroscopy.
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- Mutant isocitrate dehydrogenase 1 (mIDH1) creates excess 2-hydroxyglutarate (2HG), leading to changes in gene expression and making mIDH1 gliomas more resilient to DNA damage and radiation.* -
- Research found mIDH1 glioma cells showed reduced mitochondrial metabolism and increased autophagy, which became their main energy source, indicating they rely heavily on autophagy for survival.* -
- Blocking autophagy weakened the growth of mIDH1 glioma cells and, when combined with radiation, enhanced treatment effectiveness, suggesting targeting autophagy could improve therapies for mIDH1 glioma patients.*
The present study aimed to identify endogenous milk peptides for species differentiation independent of heat exposure. Thus, comprehensive milk peptide profiles from five species and three types of heat treatments were analyzed by micro-flow liquid chromatography ion mobility quadrupole time-of-flight mass spectrometry (microLC-IM-QTOF) with subsequent database search leading to ≥ 3000 identified peptides. In the milks, 1154 peptides were unique for cow, 712 for sheep, 466 for goat, 197 for buffalo, and 69 for mare.
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