Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm.

Purpose: Data on short courses of antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients are limited. The aim of the study was to describe and compare the frequency of bacteremia relapse, 30-day overall and infection-related mortality, Clostridiodes difficile infection and length of hospital stay since bacteremia among those who received antibiotic therapy for 7 or 14 days.

Methods: This is a multicenter, prospective, observational cohort study in adult high-risk neutropenic patients with hematologic malignancies or hematopoietic stem cell transplant and monomicrobial Enterobacterales bacteremia.

Ceftazidime-Avibactam Improves Outcomes in High-Risk Neutropenic Patients with Carbapenemase-Producing Enterobacterales Bacteremia.

Few studies have evaluated the efficacy of ceftazidime-avibactam (CA) for carbapenemase-producing Enterobacterales bacteremia (KPC-PEB) in high-risk neutropenic patients. This is a prospective multicenter observational study in high-risk neutropenic patients with multi-drug resistant Enterobacterales bacteremia. They were compared according to the resistance mechanism and definitive treatment provided: KPC-CPE treated with CA (G1), KPC-CPE treated with other antibiotics (G2), and patients with ESBL-producing Enterobacterales bacteremia who received appropriate definitive therapy (G3).

Particle swarm optimization-assisted approach for the extraction of VCSEL model parameters.

We propose a direct particle swarm optimization (PSO) method for extracting the parameters of a physical model describing the behavior of vertical-cavity surface-emitting lasers (VCSELs), starting from the light-current (L-I) characteristics and the small signal modulation (S21) responses, at different currents and temperatures. With an optimal choice of hyperparameters of the algorithm, the method is able to predict parameters that accurately reproduce the behavior of the device. Its prediction capabilities are compared to those of two commonly used nonlinear optimizers (Interior Point and Levenberg-Marquardt), to benchmark its performances.

Design and performance assessment of modular multi-band photonic-integrated WSS.

Today, optical transport and data center networks extensively utilize photonic integrated systems due to their large bandwidth and a high degree of reconfigurability. In addition to these properties, photonic integrated-based systems can deliver an overall low fabrication cost, a small footprint, and low power consumption. In this perspective, we present a modular photonic integrated multi-band wavelength selective switch (WSS) capable of managing a wide spectrum, covering the three S+C+L bands, and potentially scalable to larger numbers of output fibers and routed channels.