Publications by authors named "A Care"
Article Synopsis
- Regulatory T (Treg) cells are crucial for maintaining immune tolerance during pregnancy, ensuring that the mother’s body accepts the developing fetus and placenta.
- In a study using a specific mouse model, researchers found that depleting Treg cells early in pregnancy led to problems with the remodeling of uterine arteries, reduced natural killer (uNK) cell numbers, and resulted in fetal loss and growth restriction.
- By transferring Treg cells from healthy donors, the negative effects on vascular function and fetal health were mitigated, highlighting the important role Treg cells play in adapting the uterine environment for a successful pregnancy and their connection to issues like preeclampsia.
Gender medicine studies how health status and diseases differ between men and women in terms of prevention, therapeutic approach, prognosis, and psychological and social impact. Sex and gender analyses have been demonstrated to improve science, contributing to achieving real appropriateness and equity in the cure for each person. Therefore, it is fundamental to consider, both in preclinical and clinical research, the different clinical and biological features associated with sex and/or gender, where sex differences are mainly influenced by biological determinants and gender ones by socio-cultural and economic matters.
View Article and Find Full Text PDFNeuronanomedicine is an emerging field bridging the gap between neuromedicine and novel nanotherapeutics. Despite promise, clinical translation of neuronanomedicine remains elusive, possibly due to a dearth of information regarding the effect of the protein corona on these neuronanomedicines. The protein corona, a layer of proteins adsorbed to nanoparticles following exposure to biological fluids, ultimately determines the fate of nanoparticles in biological systems, dictating nanoparticle-cell interactions.
View Article and Find Full Text PDFArticle Synopsis
- Regulatory T (Treg) cells are crucial for preventing early pregnancy loss, and boosting these cells may improve reproductive success in problematic cases.
- A study using an abortion-prone mouse model showed that administering a specific IL-2 treatment (IL-2/JES6-1) significantly increased the number of beneficial Treg cells in the uterus, leading to improved fetal outcomes.
- Although the treatment reduced the rate of fetal loss from 31% to 10%, it also resulted in a slight decrease in fetal weight during late gestation, indicating potential trade-offs that need further exploration.
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.
Am J Physiol Heart Circ Physiol
July 2024
Maternal mortality rates are at an all-time high across the world and are set to increase in subsequent years. Cardiovascular disease is the leading cause of death during pregnancy and postpartum, especially in the United States. Therefore, understanding the physiological changes in the cardiovascular system during normal pregnancy is necessary to understand disease-related pathology.
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