Publications by authors named "A Carattoli"
Cefiderocol (FDC), a siderophore-cephalosporin conjugate, is the newest option for treating infection with carbapenem-resistant gram-negative bacteria. We identified a novel mechanism contributing to decreased FDC susceptibility in Klebsiella pneumoniae clinical isolates. The mechanism involves 2 coresident plasmids: pKpQIL, carrying variants of bla carbapenemase gene, and pKPN, carrying the ferric citrate transport (FEC) system.
View Article and Find Full Text PDFIntroduction: The genus is assuming greater clinical relevance among infections caused by also because of its intrinsic and acquired resistance to last-resort antibiotics. However, despite having been known and studied for over 50 years, genomics and taxonomy of the genus are currently undergoing a deep rearrangement. In this study we aim to outline and characterized the species.
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- Carbapenemase-producing bacteria, particularly KPC-3-producing sequence type (ST) 512, pose a significant global health threat, with increasing resistance to advanced treatments like ceftazidime/avibactam (CZA).
- This study analyzed three isolates from a single patient over 78 days, including two that originated from a liver abscess, focusing on their antimicrobial resistance and genetic characteristics.
- The final isolate, hmv-318Kp, demonstrated CZA resistance and a hypermucoviscous phenotype due to specific genetic mutations, indicating an evolution of this strain in terms of infectivity and resistance mechanisms.
Nearly a century after the beginning of the antibiotic era, which has been associated with unparalleled improvements in human health and reductions in mortality associated with infection, the dwindling pipeline for new antibiotic classes coupled with the inevitable spread of antimicrobial resistance (AMR) poses a major global challenge. Historically, surveillance of bacteria with AMR typically relied on phenotypic analysis of isolates taken from infected individuals, which provides only a low-resolution view of the epidemiology behind an individual infection or wider outbreak. Recent years have seen increasing adoption of powerful new genomic technologies with the potential to revolutionise AMR surveillance by providing a high-resolution picture of the AMR profile of the bacteria causing infections and providing real-time actionable information for treating and preventing infection.
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