Publications by authors named "A Capra"
One of the most used chemotherapy agents in clinical practice is 5-Fluorouracil (5-FU), a fluorinated pyrimidine in the category of antimetabolite agents. 5-FU is used to treat a variety of cancers, including colon, breast, pancreatic, and stomach cancers, and its efficacy lies in its direct impact on the patient's DNA and RNA. Specifically, its mechanism blocks the enzymes thymidylate synthetase and uracil phosphatase, inhibiting the synthesis of uracil, which cannot be incorporated into nuclear and cytoplasmic RNA.
View Article and Find Full Text PDFSpinal cord injury (SCI) leads to severe and lasting impairments in motor and sensory functions. The intense inflammatory response following SCI is a significant challenge, and autophagy has emerged as a key factor in the recovery process. The C-C chemokine receptor type 1 (CCR1), a G-protein coupled receptor, plays a crucial role in managing the chemokine response under stress.
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- * Genetic mutations in the LRRK2 gene are significant as they increase LRRK2 activity, disrupting neuronal autophagy and contributing to neurotoxicity and neuron death.
- * The review explores how the upregulation of casein kinase (CK) affects the AMPK pathway and contributes to disease processes in NDDs by impacting proteins associated with diseases like PD, HD, and AD, highlighting the role of kinases in their development.
Article Synopsis
- * Benzyl isothiocyanate (BITC), a natural compound, has shown potential anticancer effects in ATC, influencing crucial cellular processes.
- * The study suggests that BITC may slow ATC progression by interacting with autophagy, reducing epithelial-mesenchymal transition (EMT), and lowering inflammation, indicating it warrants further research for new treatment approaches.
Article Synopsis
- GERD is a common stomach problem that affects many people and causes changes in the esophagus due to inflammation.
- Researchers studied a substance called bombesin to see if it could help reduce inflammation and stomach pain in mice with GERD.
- The results showed that bombesin helped lower pain and improve stomach conditions, suggesting it could be a good treatment option for people with GERD.