Publications by authors named "A Caobi"
Article Synopsis
- Extracellular vesicles (EVs), particularly exosomes (xEVs), have been linked to the progression of Diffuse Large B-cell Lymphoma (DLBCL) and contain important biomolecules such as proteins and nucleic acids.
- In the context of HIV, the expression of these xEVs has been associated with disease progression, highlighting their potential clinical relevance.
- Research indicates that the biomolecules in xEVs can aid in detecting disease progression and may help in predicting treatment outcomes for DLBCL, particularly in HIV-infected patients.
SARS-CoV-2 exhibits a remarkable capability to subvert the host antiviral innate immune system. This adeptness is orchestrated by viral proteins, which initially attempt to obstruct the activation of the antiviral immune program and then act as a fail-safe mechanism to mitigate the downstream effects of the activated immune response. This dual strategy leads to delayed expression and enfeebled action of type-I and -III interferons at the infection site, enabling the virus to replicate extensively in the lungs and subsequently disseminate to other organs.
View Article and Find Full Text PDFLiquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomes contain proteins and nucleic acids (DNA/RNA) that can modify the microenvironment and promote cancer progression, playing significant roles in cancer pathology.
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- Opiate abuse is linked to a higher risk of HIV transmission and worsens HIV-related nerve damage by affecting inflammation and immune responses.
- This study focuses on the development of a unique exosomal miRNA biomarker profile for HIV-infected cells, specifically looking at how morphine influences these miRNAs.
- Findings indicate that HIV and morphine together alter miRNA levels, which can impact neuronal function, suggesting potential new targets for treatment or understanding the disease mechanisms.
Exosomal extracellular vesicles (xEVs) in plasma and cerebrospinal fluid (CSF) of aviremic people living with HIV/AIDS (PLWHA) contain the HIV Negative factor (Nef) protein. However, the role of xEVs and Nef-containing-xEVs(xEV-Nef) in HIV-associated neuropathology is unknown. Here we performed a cross-sectional analysis of the content of xEVs derived from matched serum and CSF samples of PLWHAs diagnosed with either asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), or HIV-associated dementia (HAD).
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