Publications by authors named "A Cantin"
Background And Purpose: The addition of interstitial needles to intracavitary gynecologic (GYN) high dose rate (HDR) brachytherapy has been shown to improve target coverage and organs-at-risk (OAR) sparing. However, no commercial solution allows real-time guidance of interstitial catheter placement. This phantom study aimed to evaluate the feasibility of an electromagnetic (EM) tracking system guidance workflow for GYN HDR brachytherapy treatment in a magnetic resonance imaging (MRI) and real-time transrectal ultrasound (TRUS) fusion scenario.
View Article and Find Full Text PDFTo quantify concentration and encapsulation efficiency (EE) of mRNA in lipid nanoparticles (LNPs) the RiboGreen assay is extensively used. As part of this assay, a surfactant is used to release mRNA from LNPs for detection with the RiboGreen dye. So far, the surfactant of choice has been Triton X-100, which is harmful to human health and the environment.
View Article and Find Full Text PDFLake St. Charles, located north of Quebec City, Canada, is a shallow fluvial lake with two distinct basins bridging rural and urban landscapes. Mainly used as a source of drinking water for 300,000 residents, the lake has faced a steady degradation in water quality due to urbanization and the discharge of domestic wastewater.
View Article and Find Full Text PDFBackground: Individuals affected by the post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicates the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases.
Methods: Twenty-five women and men with PCC were assigned sequentially to exercise ( = 15) and non-exercise ( = 10) groups.
Article Synopsis
- Lung parenchymal hypoxia is a key characteristic of idiopathic pulmonary fibrosis (IPF), which enhances cancer cell invasion and promotes lung fibrogenesis through LPA-dependent signaling.
- Research shows that lung fibroblasts from IPF patients create invadosomes—structures that degrade the matrix—more effectively, suggesting a correlation between invadosome formation and fibrosis severity.
- The study finds that hypoxia boosts invadosome formation through LPA and PDGFR-Akt signaling pathways, indicating potential therapeutic targets for reducing lung fibrosis.