Publications by authors named "A Canete Nieto"
Circuit dysfunction in autism may involve a failure of homeostatic plasticity. To test this, we studied parvalbumin (PV) interneurons which exhibit rapid homeostatic plasticity of intrinsic excitability following whisker deprivation in mouse somatosensory cortex. Brief deprivation reduces PV excitability by increasing Kv1 current to increase PV spike threshold.
View Article and Find Full Text PDFBackground: The prognosis of patients with anaplastic thyroid cancer (ATC) remains dismal. A small portion of patients experience longterm survival and need to be identified before treatment allocation. Survival scores may guide clinicians making more informed decisions about treatment options and improve the understanding of patients' prognosis.
View Article and Find Full Text PDFThis study evaluates the neuropsychological profiles of three adolescent females with suspected Autism Spectrum Disorder (ASD). The study was conducted at My Blue Side, a support organization in Southern Tenerife. The research included a detailed assessment using standardized neuropsychological tests to identify the neuropsychological characteristics associated with ASD in adolescent females.
View Article and Find Full Text PDFArticle Synopsis
- - The development of the CompOsite iNdexes For Response in asthMa (CONFiRM) aimed to create patient-centered tools that measure responses to biologics for severe asthma in both adults and children, integrating clinical data and quality of life (QoL) indicators.
- - Experts and patients collaborated to identify significant outcome changes and devised CONFiRM scores, which demonstrated high levels of agreement on key factors, with patients emphasizing the importance of quality of life more than healthcare professionals did.
- - The CONFiRM scores effectively measure treatment response, with strong validity metrics indicating their reliability, and they facilitate a comprehensive assessment of biologics’ effectiveness; further studies are required for prospective validation.
Article Synopsis
- An elevated lactate/albumin ratio (LAR) greater than 0.5 in critically ill pediatric patients is linked to higher mortality and microcirculation issues, particularly in children with sepsis.
- In a study involving 178 children admitted to the PICU, those with septic shock showed significantly higher chances of having an elevated LAR and more microvascular blood flow abnormalities.
- The findings suggest that a normal LAR indicates less risk of microcirculatory injury, making LAR a valuable biomarker for assessing sepsis-related complications in pediatric patients.