Publications by authors named "A Campos-Murguia"
Background And Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading indication for liver transplantation (LT), but also occurs after LT. The prevalence of de novo MASLD (dnMASLD) after LT, based on both surveillance (svLbx) and indication biopsies (indLbx), is unknown. Furthermore, the impact of the distinct cardiometabolic risk factors on histological disease activity has not been assessed.
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- - The R-LIVER registry, initiated by the European Reference Network on Hepatological Diseases, analyzed the presentation and outcomes of autoimmune hepatitis (AIH) in 231 patients across six European centers over a year.
- - After 6 months, 50% of patients achieved complete biochemical response (CBR), with a rise to 63% by the 12-month mark, but only 27% managed to achieve this without steroids during the first year.
- - Results indicate significant variability in AIH treatment, with many patients experiencing treatment changes due to intolerance, and highlight the need for improved strategies given the low CBR rates and challenges in steroid withdrawal.
Article Synopsis
- The study investigates the link between myostatin levels, sarcopenia, and the development of acute-on-chronic liver failure (ACLF) in cirrhosis patients, finding a progressive decrease in myostatin as cirrhosis worsens.
- Out of 186 patients, 27.9% experienced acute decompensation and 25.8% developed ACLF, with infections being a common trigger.
- Myostatin levels were found to be predictive of ACLF and patient survival, highlighting its potential role in monitoring and managing cirrhosis progression.
Introduction: Torque teno virus (TTV) replication is controlled by immune status, mirroring a degree of immunosuppression after solid organ transplantation. TTV viraemia (TTVv) was associated with acute cellular rejection and infection within the first year after liver transplantation (LT). Long-term data on TTV after LT and correlation with graft injury from protocol biopsies are limited.
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