Publications by authors named "A Campobassi"
Article Synopsis
- Soft tissue sarcomas make up a rare group of tumors accounting for just 1% of solid cancers, with liposarcoma being a notable subtype.
- The study focused on 21 patients with atypical lipomatous tumors/well differentiated liposarcoma (ALT/WDLPS) and dedifferentiated liposarcoma (DDLPS), investigating the role of biomarkers CDK4 and MDM2.
- Results indicated that CDK4 was more highly expressed in DDLPS than in ALT/WDLPS, and the CDK4 inhibitor palbociclib showed promise in a sequential treatment approach when combined with lenvatinib, suggesting a new management strategy for DDLPS.
Background: Polymorphous adenocarcinoma (PAC) represents the second most widespread neoplasm of the minor salivary glands. These tumors rarely develop a histological progression from low-grade to high-grade malignancy, named "high-grade transformation" (HGT). Only nine cases are described in literature.
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- - Adult rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma, making up less than 3% of cases, which leads to limited understanding of its clinical management and natural history.
- - Researchers studied the molecular biology of adult RMS, focusing on gene expression related to cell transition and drug resistance, utilizing patient-derived cultures and 3D models to assess drug response.
- - Key findings include the identification of potential biomarkers for RMS through RT-PCR, the highest drug sensitivity in anthracycline-based treatments, and significant genetic mutations linked to poor prognosis, contributing to a better understanding of this rare cancer.
Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma (OSCC), a tumor associated with different clinical outcomes and linked to human papilloma virus (HPV) status. Translational research has few available models with which to study the different pathophysiological behavior of OSCCs. The present study proposes a 3-dimensional (3D) biomimetic collagen-based scaffold to mimic the tumor microenvironment and the crosstalk between the extracellular matrix (ECM) and cancer cells.
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