Publications by authors named "A Caminero"
Objective: To ascertain the changes of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) values in relapsing-remitting multiple sclerosis (RRMS) patients treated with ocrelizumab and their association with treatment response.
Methods: Multicenter prospective study including 115 RRMS patients initiating ocrelizumab treatment between February 2020 and March 2022 followed during a year. Serum samples were collected at baseline and every 3 months to measure sNfL and sGFAP levels using single-molecule array (SIMOA) technology.
Article Synopsis
- The gut microbiome is crucial for our body's functioning, but the effects of non-nutritious food components on it are often ignored.
- Certain food additives and microplastics may negatively impact the gut microbiome and human health, and understanding the mechanisms behind this is essential.
- Recommendations include integrating gut microbiome research into food safety assessments to better evaluate the risks of food additives and contaminants.
Background: The assessment of serum neurofilament light chain (sNfL) concentration in multiple sclerosis (MS) is a useful tool for predicting clinical outcomes and assessing treatment response. However, its use in clinical practice is still limited. We aimed to assess how measurement of sNfL influences neurologists' treatment decisions in MS.
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- Imbalances in proteolytic activity are linked to inflammatory bowel diseases (IBD), where intestinal proteases can disrupt homeostasis and promote inflammation through protease-activated receptors (PARs).
- This study focuses on the role of microbial proteases in activating PAR2 and found that proteolytic cleavage of PAR2 increases intestinal permeability and inflammation during colitis.
- Mice with a mutated, protease-resistant version of PAR2 showed less severe colitis, suggesting that targeting PAR2 cleavage by bacterial proteases could be a potential therapeutic approach for IBD.