Publications by authors named "A Caliendo"
Background: The extent of the SARS-CoV-2 short-term evolution under Remdesivir (RDV) exposure and whether it varies across different upper respiratory compartments are not fully understood.
Methods: Patients hospitalized for COVID-19, with or without RDV therapy, were enrolled and completed up to three visits, in which they provided specimens from four respiratory compartments. Near full-length genome SARS-CoV-2 sequences were obtained from viral RNA, standard lineage and variant assignments were performed, and viral mutations in the RNA-dependent RNA polymerase (RdRp) region-the RDV target gene-were detected and compared between participants with and without RDV, across the four compartments, within participants across visits, and versus a larger sequence dataset.
Eosinophilia is known to be associated with a multitude of co-morbidities. However, unexplained eosinophilia poses a diagnostic challenge, and the methods used to investigate unexplained eosinophilia vary from region to region. In this case report, we describe a unique case of a young female presenting with marked eosinophilia to a tertiary hospital in the northeastern United States.
View Article and Find Full Text PDFThis paper demonstrates how Longitudinal Qualitative Research (LQR) is an innovative method to understand the lived experiences of members of minoritized groups when temporality is a structuring element of their experiences. Most qualitative research in psychology is cross-sectional, which limits our understanding of individuals whose experiences are context-dependent and linked to the temporal norms of specific social environments. LQR is unique for allowing researchers to compare change and stability over time and reveal how social challenges and barriers impact perspective shifts and long-term decision-making.
View Article and Find Full Text PDFArticle Synopsis
- Targeting the interactions between tumor cells and their surrounding stroma presents a new approach for cancer therapy, potentially improving treatment efficacy against tumor growth, progression, and resistance to chemotherapy.
- Researchers developed gold-core/silica-shell nanoparticles embedded with an iridium(III) complex and decorated them with aptamers that target specific receptors (EGFR and PDGFRβ) on tumor and stromal cells, respectively.
- Results demonstrated that these dual-targeted nanoparticles entered and killed cancer cells more effectively than those targeting only one receptor, especially in complex stroma-rich tumor models, indicating a promising strategy in cancer treatment.