Publications by authors named "A Caldas"
Efficacy and safety of an algorithm using C-reactive protein to guide antibiotic therapy applied through a digital clinical decision support system: a study protocol for a randomised controlled clinical trial.
BMJ Open
January 2025
Introduction: The escalating resistance of microorganisms to antimicrobials poses a significant public health threat. Strategies that use biomarkers to guide antimicrobial therapy-most notably Procalcitonin (PCT) and C-reactive protein (CRP)-show promise in safely reducing patient antibiotic exposure. While CRP is less studied, it offers advantages such as lower cost and broader availability compared with PCT.
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- - Environmental enrichment in captivity is meant to improve the well-being of fish by simulating their natural habitat, but its effects on fish reproduction are not well understood.
- - In a study with twospot astyanax larvae, fish raised in enriched environments (with PVC pipes, stones, and plants) exhibited healthier reproductive structures compared to those in sterile environments.
- - Results indicated that sterile-reared fish showed early spawning and potential reproductive issues, leading to lower-quality offspring, whereas enriched fish had better-developed gametes and healthier larval outcomes.
The aim of this study was to investigate the correlation between depressive symptoms and the occurrence of oral mucositis in children with oncological diseases treated at a reference hospital. This was a cross-sectional study conducted with individuals aged 4 to 18 years, diagnosed with primary neoplasms. Data was collected by using a questionnaire that assessed the degree of oral mucositis according to the World Health Organization index, the risk of oral mucositis according to the Child's International Mucositis Evaluation Scale, and depressive symptoms using the Children's Depression Inventory.
View Article and Find Full Text PDFLoss of and high COX2 () expression in metastatic colorectal cancer.
Ecancermedicalscience
February 2024
Lack of expression of the tumour suppressor gene caudal-type homeobox 2 () associates with poor outcomes in early stage colorectal cancer (CRC). Yet its prognostic value in the context of other prognostic biomarkers in metastatic CRC (mCRC) is unknown. Overexpressed cyclooxygenase-2 (COX2) has been reported in advanced CRC.
View Article and Find Full Text PDFUnlabelled: The antiviral properties of the extracts of nests collected from the Black Sea, Turkey have been investigated on (Sf) cell cultures of multicapsid nuclear polyhedrosis virus (AcMNPV). The effect of nests on cell viability and cytotoxicity analysis and the antiviral assay was studied, and the cytopathic effects of the virus were detected. The nest's viral content was identified.
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