Systemic and haemodynamic toxicity after isolated limb perfusion (ILP) with TNF-alpha.

The aim of this study was to evaluate the systemic and haemodynamic postoperative effects of ILP with medium-low dose of TNF alpha in patients diagnosed with primary or recurrent limb melanoma or sarcoma, and to compare the resulting toxicity with Systemic Inflammatory Response Syndrome (SIRS). A prospective study on 17 consecutive patients with primary or recurrent limb tumor (melanoma or sarcoma) subjected to ILP with escalating doses of TNF alpha (0.5-2.

Toxic shock syndrome due to group C streptococci. A case report.

Background: Streptococcal toxic shock-like syndrome is a life-threatening illness which is on the increase. In early reports, only group A beta-hemolytic streptococcus was associated with the disease, but recent evidence indicates non-A streptococci groups are also involved.

Observations: We describe the first reported case of streptococcal toxic shock-like syndrome caused by a group C strain in Italy.

[Thrombocytopenia and thrombophilic state in heparin therapy].

The authors report two clinical cases of thrombocytopenia and thrombosis which occurred during profilaxys and therapy with heparin. The mechanisms involved are reviewed and the possible therapeutic role of heparin-like drugs is discussed according to data presented in the international literature.

[Tetraplegia and acute respiratory insufficiency from an ischemic cervical medulla lesion after cocaine use. A clinical case].

The article deals with a case report on tetraplegia and acute respiratory failure following ischemic damage of the spinal medulla in the cervical tract due to cocaine assumption. The ischemic damaged produced by cocaine usually injure the great vessels of the cranial base. The case report is particular because of the area and the seize of the injured vessel.