Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner.

In contrast to the thoroughly characterized mechanisms of positive regulation within cytokine signaling pathways, our knowledge of negative feedback loops is comparatively sparse. We and others have previously reported that IRAK-M down-regulates inflammatory responses to multiple stimuli. In particular, we could show that the nitric oxide (NO) donor, GSNO, induces IRAK-M overexpression in human monocytes.

Management of neurogenic bladder dysfunction secondary to myelomeningocele.

We investigated 55 children, aged from 24 months to 14 years with neurogenic bladder dysfunction secondary to myelomeningocele, by serial urodynamic. They were serially evaluation over 2-5 years. Management consisted of drug therapy together with intermittent vesical catheterization in different combinations on the basis of initial urodynamic assessment.

[Treatment of neurogenic bladder secondary to myelomeningocele based on the urodynamic status with intermittent catheterization associated with drugs. Preliminary results].

The follow-up of 36 children with neurogenic urinary bladder, aged from 3.5 months to 12 years is reported. The were serially evaluated with tonometry of detrusor muscle and urethral sphincter.