Publications by authors named "A CARRARO"
Following viral infection, antigen-restricted T lymphocytes are activated and recognize infected cells to eliminate them. A subset of T cells differentiates into memory lymphocytes able to counteract viral rechallenge in a faster and enhanced way. SARS-CoV-2 can escape immune responses leading to a poor clinical outcome.
View Article and Find Full Text PDFUnderstanding the current dietary habits of college students is essential due to the pressing issues of unbalanced diets and insufficient nutrition. However, traditional approaches frequently depend on recollection, which can introduce unconscious bias and make them difficult to implement. Herein, we introduce a new computer vision system to evaluate the dietary habits of college students in China.
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- Low-grade endotoxemia, caused by lipopolysaccharide (LPS), is detected in COVID-19 patients, potentially promoting thrombosis through a pro-inflammatory and pro-coagulant state.
- The study measured various biomarkers in 175 COVID-19 patients and 50 healthy controls, finding significantly elevated levels of markers like sNOX2-dp and D-dimer in COVID-19 patients, especially those with acute respiratory distress syndrome (ARDS).
- Results suggest that factors like impaired gut barrier function, high NOX2 activation, and low albumin may lead to low-grade endotoxemia, increasing the risk of thrombotic events in COVID-19 patients.
Article Synopsis
- In kidney transplant recipients, BK polyomavirus-associated nephropathy (BKPyVAN) is a significant risk for transplant loss, and reducing immunosuppression to manage BKPyV-DNAemia can also heighten the risk of graft rejection.
- The CERTAIN study, involving 195 pediatric kidney transplant recipients, found that BKPyV-DNAemia significantly increased the risk of T cell-mediated rejection, development of donor-specific antibodies, and overall decline in graft function.
- The findings suggest that careful monitoring and regular screening for donor-specific antibodies are essential when adjusting immunosuppressive therapy in patients with BKPyV-DNAemia to mitigate rejection risks.
Background: This study by the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) was designed to determine the incidence, risk factors, current management strategies, and outcomes of antibody-mediated rejection (ABMR) in pediatric kidney transplant recipients (pKTR).
Methods: We performed an international, multicenter, longitudinal cohort study of data reported to the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry. Three hundred thirty-seven pKTR from 21 European centers were analyzed.