In silico drug repurposing at the cytoplasmic surface of human aquaporin 1.

Aquaporin 1 (AQP1) is a key channel for water transport in peritoneal dialysis. Inhibition of AQP1 could therefore impair water transport during peritoneal dialysis. It is not known whether inhibition of AQP1 occurs unintentionally due to off-target interactions of administered medications.

Public Health.

Background: Alzheimer's disease (AD) health literacy is low in high-risk populations and is likely a determinant of timely care seeking behavior. Our group aimed to develop a novel brief questionnaire for use in community outreach and related studies of AD awareness.

Methods: We developed an initial 15-item AD knowledge questionnaire "ASK-AD (Assess Symptoms and Knowledge of AD)" following pilot study and cognitive interviews with subject matter experts along with elementary school children.

No decision about me, without me: Collaborating with young people in mental health research.

Involving young people with lived experience in youth mental health research is important. In recognition of the value of collaborating with experts by experience, international funders are increasingly mandating that mental health research is developed by teams that include individuals from the population of study. Yet, research into how Patient Public Involvement, specifically co-production and co-design, is implemented in youth mental health research is limited to date.

Examining longitudinal associations between interpersonal outcomes and general psychopathology factors across preadolescence using random intercept cross-lagged panel model.

Background: Interpersonal outcomes and mental health problems are closely associated. However, their reciprocal influence has not been directly examined while considering the temporal stability of these constructs, as well as shared and unique variance associated with internalising, externalising and attention problems. Using random intercept cross-lagged panel models (RI-CLPM), we tested the hypotheses that negative bidirectional associations at the between-person and negative cross-lagged effects at the within-person level would emerge between interpersonal outcomes (friendship quality and perceived popularity) and mental health problems (i.