Strategies to improve recruitment in mental health clinical trials: a scoping review (RE-MIND study).

Background: Lower-than-expected recruitment continues to be one of the major causes of trial delays, and trials to improve mental health are no exception. Indeed, recruitment challenges in trials of vulnerable populations, such as those living with mental health illness, can even be exacerbated. To address this, researchers are turning to digital and online recruitment strategies, e.

Let's (P-s)talk about specialized ribosomes.

In a recent study in Cell, Dopler et al. show that a subpopulation of P-stalk-containing ribosomes (PSRs) are generated following exposure to cytokines, and the data suggest that PSRs are central mediators of translational reprogramming during the cytokine- and immune-response.

Cross-Sex Hormone Therapy Is Associated With Loss of Circadian Rhythm in the Male Rat.

Background: Transgender women are individuals born male but identify as female. Many transgender women undergo gender-affirming hormone therapy to alleviate the distress that can occur due to gender incongruence. For transgender women, gender-affirming hormone therapy includes 17β-estradiol (E2) combined with an antiandrogen therapy (AA) or surgical intervention.

Host DNA depletion on frozen human respiratory samples enables successful metagenomic sequencing for microbiome studies.

Most respiratory microbiome studies use amplicon sequencing due to high host DNA. Metagenomics sequencing offers finer taxonomic resolution, phage assessment, and functional characterization. We evaluated five host DNA depletion methods on frozen nasal swabs from healthy adults, sputum from people with cystic fibrosis (pwCF), and bronchoalveolar lavage (BAL) from critically ill patients.

Defining key deprescribing measures from electronic health data: A multisite data harmonization project.

Background: Stopping or reducing risky or unneeded medications ("deprescribing") could improve older adults' health. Electronic health data can support observational and intervention studies of deprescribing, but there are no standardized measures for key variables, and healthcare systems have differing data types and availability. We developed definitions for chronic medication use and discontinuation based on electronic health data and applied them in a case study of benzodiazepines and Z-drugs in five diverse US healthcare systems.