Publications by authors named "A C Westerkamp"
Article Synopsis
- Methylphenidate (MPH) is commonly prescribed for attention-deficit/hyperactivity disorder, but some patients require unusually high doses, possibly due to genetic differences affecting drug metabolism.
- A study involving three patients taking doses between 180 to 640 mg of MPH found that their plasma concentrations were lower than expected, indicating a faster metabolism of the drug.
- However, genetic testing of the CES1 gene did not reveal any variants that could account for the increased clearance of MPH in these patients, suggesting other factors may be involved in their high dosage needs.
Chronic pain is a major problem for patients with Charcot-Marie-Tooth (CMT) disease. This exploratory study examined patient reported efficacy of medical cannabis for pain management in this population. Participants (N = 56; 71.
View Article and Find Full Text PDFIntroduction: Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy. We investigated whether addition of metformin before or during ex vivo isolated normothermic machine perfusion (NMP) of porcine and rat kidneys affects its elimination.
View Article and Find Full Text PDFMetformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, saline or 300 mg/kg metformin was administered orally twice on the day before nephrectomy.
View Article and Find Full Text PDFBackground: Preconditioning of donor livers before organ retrieval may improve organ quality after transplantation. We investigated whether preconditioning with metformin reduces preservation injury and improves hepatobiliary function in rat donor livers during ex situ normothermic machine perfusion (NMP) and after orthotopic liver transplantation.
Methods: Lewis rats were administered metformin via oral gavage, after which a donor hepatectomy was performed followed by a standardized cold storage period of 4 hours.