Publications by authors named "A C Wakeham"
PirB is an inhibitory cell surface receptor particularly prominent on myeloid cells. PirB curtails the phenotypes of activated macrophages during inflammation or tumorigenesis, but its functions in macrophage homeostasis are obscure. To elucidate PirB-related functions in macrophages at steady-state, we generated and compared single-cell RNA-sequencing (scRNAseq) datasets obtained from myeloid cell subsets of wild type (WT) and PirB-deficient knockout (PirB KO) mice.
View Article and Find Full Text PDFHMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.
Proc Natl Acad Sci U S A
September 2023
Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to the extracellular space. In the cytoplasm, HMGB1 induces autophagy impairing asbestos-induced cell death.
View Article and Find Full Text PDFCholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It remains unclear whether there is any form of cholinergic regulation of liver cancer.
View Article and Find Full Text PDFArticle Synopsis
- - Current vaccines target the spike protein of SARS-CoV-2, but the receptor-binding domain (RBD) is the most important part for inducing immune responses, accounting for 90% of neutralization activity.
- - Researchers created various RBD versions and tested their effectiveness in mice, finding that a specific subdomain was crucial for strong immune responses and that certain production methods and adjuvants enhanced these responses.
- - The Beta version of the optimized RBD-based vaccine showed broad-spectrum effectiveness against multiple COVID variants and provided complete protection in vaccinated mice, making it a promising candidate for clinical trials.