Highly Reliable BiOSe Dendritic Neuron Enabling Spatial-Temporal Signal Processing for Real-World Image Classification.

Artificial intelligence (AI) has made significant strides by imitating biological neurons and synapses through simplified models, yet incomplete neuron functionalities can limit performance and energy efficiency in handling complex tasks. Biological neurons process input signals nonlinearly, utilizing dendrites to process spatial-temporal information. This study demonstrates the compact artificial dendrite device employing memristors based on bismuth oxyselenide (BiOSe).

GUIDANCE study: guided growth of the proximal femur to prevent further hip migration in patients with cerebral palsy-study protocol for a multicentre randomised controlled trial.

Introduction: Up to one-third of patients with cerebral palsy (CP) develop hip migration. Current standard care for early hip migration is bilateral adductor-psoas tenotomy; however, the failure rate is relatively high with 34%-74% of patients with CP requiring secondary hip surgery. Using temporary medial hemiepiphysiodesis of the proximal femur (TMH-PF), the morphology of the hip can be changed.

A Call for Clarity: A Proposed Toolkit to Integrate Foundational Sciences into Pharmacy Curricula.

The American College of Clinical Pharmacy (ACCP) Pharmacotherapy Didactic Curriculum Toolkit has been used across many schools of pharmacy to guide the depth and breadth of therapeutics coverage, but no counterpart for foundational science coverage in pharmacy education currently exists. Broad topic areas for the foundational sciences are outlined in Appendix 1 of the Accreditation Council for Pharmacy Education (ACPE) standards, but the standards lack specific direction with regard to foundational sciences content needed in the professional pharmacy curriculum. Faculty are therefore challenged to determine the depth and breadth of foundational sciences to meet educational standards within limited curricular space, often resulting in curricular hoarding and overload.

Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation.

Cognitive impairment is a common but poorly understood non-motor aspect of Parkinson's disease, negatively affecting patient's functional capacity and quality of life. The mechanisms underlying cognitive impairment in Parkinson's disease are still elusive, limiting treatment and prevention strategies. This study investigates the molecular and cellular basis of cognitive impairment associated with heterozygous mutations in GBA1, the strongest risk gene for Parkinson's disease that encodes glucocerebrosidase (GCase), a lysosome enzyme that degrades the glycosphingolipid glucosylceramide into glucose and ceramide.