Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression.

AMPK's role in tumor initiation and progression is controversial. Here, we provide genetic evidence that AMPK is required for metastasis in mouse models of breast cancer. In a mouse model of spontaneous breast cancer metastasis, the deletion of AMPK before and after tumor onset decreased breast cancer metastasis, and similar results were obtained after AMPK deletion in breast cancer cell lines.

How Many Trauma Admissions Require Acute Trauma Team Interventions?

Introduction: The aim of this study was to assess the percentage of trauma patients admitted and receiving intervention, and to identify which of these interventions were performed by non-trauma specialists.

Methods: The authors conducted a retrospective chart review of all adult patients who presented to the trauma service between January 2019 and June 2019. Collected data included demographics, trauma activation level, total interventions performed, interventions performed by the trauma team, interventions performed by subspecialty teams, and isolated injuries requiring orthopedic, neurosurgical, or other specialized care.

Comparative Outcomes of a Cognitive-Behavioral Skills Building Program on the Mental Health and Healthy Behaviors of Prenursing Students.

Background: Nursing students experience significantly more stress related diseases when compared to non-nursing students, and the state of their mental health can result in short-term increased attrition rates and increased nursing shortages.

Purpose: A preexperimental pre-post study design was used to examine mental health and healthy behaviors among prenursing students.

Methods: Cohorts received the MINDSTRONG© program either in-person or virtually.

Propagation of Orientation Across Lengthscales in Sheared Self-Assembling Hierarchical Suspensions via Rheo-PLI-SAXS.

Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably, it is observed that mesoscale alignment in the flow direction does not develop simultaneously across nano-micro lengthscales in sheared suspensions of rod-like chiral-nematic (meso) phase forming cellulose nanocrystals. Rather, with increasing shear rate, orientation is observed first at mesoscale and then extends to the nanoscale, with influencing factors being the aggregation state of the hierarchy and concentration.