Publications by authors named "A C T Nieuwenhuizen"
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frailty).
View Article and Find Full Text PDFMuscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have sex-specific features in humans, but it is not yet assessed whether these are recapitulated in mice.
View Article and Find Full Text PDFThe course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors.
Support Care Cancer
July 2023
Purpose: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors.
Methods: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment.
Article Synopsis
- Physical weakness, a common issue in older adults, shows significant sex differences, with women experiencing a higher prevalence and earlier onset of frailty-related weakness.
- The study involved muscle biopsies from older adults, revealing that weak females had heightened inflammatory responses, while weak males displayed smaller muscle fiber size and unique molecular changes.
- The findings underscore the need for sex-specific considerations in frailty research, as these differences could inform more effective interventions for combating physical weakness in older adults.
Article Synopsis
- The prevalence of sarcopenia is on the rise, making it essential to find effective intervention tests, although existing methods can be difficult and costly.
- Researchers evaluated three mouse models that simulate factors contributing to sarcopenia: partial immobilization (sedentary lifestyle), caloric restriction (CR), and a combination of both.
- The findings suggested that the combined model best reflects human muscle aging by showing significant loss of muscle mass and function, highlighting the relevance of lifestyle factors like inactivity and poor nutrition in the development of sarcopenia.