Publications by authors named "A C Stanforth"
Article Synopsis
- Ultra high dose rate (UHDR) radiotherapy, specifically conformal FLASH proton therapy, offers potential benefits by minimizing damage to healthy tissue while effectively targeting tumors.
- Clinical application of conformal FLASH has faced challenges, particularly concerning the quality assurance of measuring dose rate (DR) and linear energy transfer (LET).
- The study successfully validated these parameters, demonstrating strong agreement between experimental data and Monte Carlo simulations, confirming the efficacy of the UHDR treatment approach.
Purpose: Improving efficiency of intensity modulated proton therapy (IMPT) treatment can be achieved by shortening the beam delivery time. The purpose of this study is to reduce the delivery time of IMPT, while maintaining the plan quality, by finding the optimal initial proton spot placement parameters.
Methods: Seven patients previously treated in the thorax and abdomen with gated IMPT and voluntary breath-hold were included.
Purpose: Quality assurance computed tomography (QACT) is the current clinical practice in proton therapy to evaluate the needs for replan. QACT could falsely indicate replan because of setup issues that would be solved on the treatment machine. Deforming the treatment planning CT (TPCT) to the pretreatment CBCT may eliminate this issue.
View Article and Find Full Text PDFPurpose: While intensity modulated proton therapy can deliver simultaneous integrated boost (SIB) to the dominant intraprostatic lesion (DIL) with high precision, it is sensitive to anatomic changes. We investigated the dosimetric effects from these changes based on pretreatment cone-beam computed tomographic (CBCT) images and identified the most important factors using a multilayer perceptron neural network (MLPNN).
Methods And Materials: DILs were contoured based on coregistered multiparametric magnetic resonance images for 25 previously treated prostate cancer patients.
Purpose: In this study, we investigated computationally and experimentally a hexagonal-pattern array of spatially fractionated proton minibeams produced by proton pencil beam scanning (PBS) technique. Spatial fractionation of dose delivery with millimeter or submillimeter beam size has proven to be a promising approach to significantly increase the normal tissue tolerance. Our goals are to obtain an optimized minibeam design and to show that it is feasible to implement the optimized minibeams at the existing proton clinics.
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