Publications by authors named "A C Sims"
Introduction: Fibromyalgia (FM) is a widespread chronic pain condition with prevalence increasing in older adults. Older adults living with FM experience longer pain symptom durations that can negatively impact their quality of life. Affect and neuroinflammation are potential factors that can exacerbate pain symptoms.
View Article and Find Full Text PDFWhile the effects of external factors like fluid mechanical forces and scaffold geometry on tissue growth have been extensively studied, the influence of cell behavior-particularly nutrient consumption and depletion within the scaffold-has received less attention. Incorporating such factors into mathematical models allows for a more comprehensive understanding of tissue-engineering processes. This work presents a comprehensive continuum model for cell proliferation within two-dimensional tissue-engineering scaffolds.
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- - The study aimed to evaluate the safety and effectiveness of treatments for recurrent respiratory papillomatosis (RRP) in UK NHS hospitals, involving data collection from patients between April 2018 and August 2022, along with some retrospective data from earlier years.
- - A total of 304 patients (including 65 children) were analyzed; findings showed that children had a more severe form of RRP compared to adults, with microdebrider surgeries being the most common treatment.
- - The research concluded that RRP is more aggressive in children, treatment varies by age, and overall management was safe, with few complications and effective results; it highlighted the need for standardized reporting to better track disease progression and safety. *
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test.
Regul Toxicol Pharmacol
November 2024
Accurately determining the mutagenicity of small-molecule N-nitrosamine drug impurities and nitrosamine drug substance-related impurities (NDSRIs) is critical to identifying mutagenic and cancer hazards. In the current study we have evaluated several approaches for enhancing assay sensitivity for evaluating the mutagenicity of N-nitrosamines in the bacterial reverse mutagenicity (Ames) test. Preincubation assays were conducted using five activation conditions: no exogenous metabolic activation and metabolic activation mixes employing both 10% and 30% liver S9 from hamsters and rats pretreated with inducers of enzymatic activity.
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- Global prevalence of knee osteoarthritis exceeds 300 million, with uncontrollable risk factors including age, sex, and height, and controllable ones like trauma, weight, and waist circumference.
- The study evaluated data from 4,602 participants aged 45-79 from the Osteoarthritis Initiative to examine the correlation between knee osteoarthritis and anthropometric measures, focusing on weight, height, and waist circumference.
- Findings showed that higher weight significantly predicted knee osteoarthritis discomfort, particularly in females, while waist circumference also played a notable role for males; quality of life was more adversely affected in females compared to males.