Publications by authors named "A C Sidebottom"
Clostridioides difficile is a leading cause of healthcare infections. Gut dysbiosis promotes C. difficile infection (CDI) and CDIs promote gut dysbiosis, leading to frequent CDI recurrence.
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- The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
- Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
- Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
Steroid hormone metabolism by the gut microbiome has multiple implications for mammalian physiology, but the underlying mechanisms and broader significance of this activity remains largely unknown. Here, we isolate a novel human gut bacterium, strain HCS.1, that reduces cortisol, progesterone, testosterone, and related steroid hormones to 3β,5β-tetrahydrosteroid products.
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- * A total of 120 patients were included; findings showed similar cervical changes between the two device types, with most patients (74.8%) achieving vaginal delivery and expressing high satisfaction, especially those using osmotic dilators.
- * The study concludes that outpatient cervical ripening is generally safe and satisfying, with low stress levels and a common recommendation for the procedure among patients.
COVID-19 in pregnancy: prevalence, management, and outcomes in a single large health system.
J Matern Fetal Neonatal Med
December 2024
Objective: This study assessed the prevalence of SARS-CoV-2 positivity in a cohort of pregnant patients served by a single health system. Treatments and outcomes are compared by maternal SARS-CoV-2 status and COVID-19 symptomatology.
Methods: This was a retrospective cohort study of patients with delivery outcomes from March 2020-December 2021.