Publications by authors named "A C Shipstone"
Article Synopsis
- The study investigates the role of branched chain amino acid (BCAA) catabolism defects in metabolic diseases and how enhancing this process could restore metabolic balance.
- The research focuses on BT2, a small molecule that inhibits BDK, an enzyme involved in BCAA breakdown, and evaluates its effects in various mouse models of metabolic dysfunction.
- Results show that BT2 treatment improves insulin sensitivity and reduces liver fat accumulation (steatosis) in multiple mouse models, altering gene expressions related to fatty acid metabolism, but BDK knockdown in the liver did not have the expected benefits, indicating complex regulatory mechanisms.
Article Synopsis
- The study investigates how the lymphatic system contributes to chronic heart problems, particularly in the context of angiotensin II-induced injuries in mice.
- Researchers found that angiotensin II caused inflammation and fibrosis in the heart over time, but co-administration of VEGFCc156s helped improve these conditions and lymphatic functions.
- The findings suggest that VEGFCc156s offers therapeutic benefits by reducing heart dysfunction, alleviating inflammation and fibrosis, and lowering blood pressure without increasing stiffness in the aorta.
Metabolic reprogramming plays a central role in T cell activation and differentiation, and the inhibition of key metabolic pathways in activated T cells represents a logical approach for the development of new therapeutic agents for treating autoimmune diseases. The widely prescribed antidiabetic drug metformin and the glycolytic inhibitor 2-deoxyglucose (2-DG) have been used to study the inhibition of oxidative phosphorylation and glycolysis, respectively, in murine immune cells. Published studies have demonstrated that combination treatment with metformin and 2-DG was efficacious in dampening mouse T cell activation-induced effector processes, relative to treatments with either metformin or 2-DG alone.
View Article and Find Full Text PDFThe Canadian beaver () is the largest indigenous rodent in North America. We report a draft annotated assembly of the beaver genome, the first for a large rodent and the first mammalian genome assembled directly from uncorrected and moderate coverage (< 30 ×) long reads generated by single-molecule sequencing. The genome size is 2.
View Article and Find Full Text PDFPostoperative thrombotic thrombocytopenic purpura following cardiovascular surgeries.
Am J Hematol
September 1996
Among 47 patients with thrombotic thrombocytopenic purpura (TTP), 8 patients were diagnosed to have postoperative-TTP. Two patients underwent vascular surgery, 5 patients coronary artery bypass grafts, and 1 patient resection of myocardial sarcoma. Prior to surgery, all patients except one had normal hemograms and platelet counts, and blood smears showed no schistocytes.
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