Publications by authors named "A C Seguro"
Article Synopsis
- The study investigated the effectiveness of N-acetylcysteine (NAC) in relieving dryness symptoms in women with Sjögren's disease through a placebo-controlled trial with 60 participants.
- Results showed no significant improvements in dryness symptoms or oxidative stress levels with NAC compared to placebo at the 30 and 90-day marks, despite higher NAC blood concentrations in the treatment group.
- The findings suggest that while NAC can be taken as a rescue therapy for Sjögren's disease, it does not significantly alleviate symptoms of dryness or oxidative stress.
. New applications of 3D printing have recently appeared in the fields of radiotherapy and radiology, but the knowledge of many radiological characteristics of the compounds involved is still limited. Therefore, studies are needed to improve our understanding about the transport and interaction of ionizing radiation in these materials.
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- Drug-induced hypomagnesemia can have serious and potentially fatal consequences, particularly from long-term use of proton pump inhibitors (PPIs), which impair magnesium absorption in the intestines.
- The mechanisms involve reduced transport of magnesium through specific cellular channels (TRPM6 and TRPM7) and a decrease in paracellular absorption due to downregulated claudins.
- Two cases are highlighted where PPI use led to electrolyte disorders resulting in cardiac arrhythmia, cognitive changes, and seizures, emphasizing the importance of monitoring magnesium levels in high-risk patients.
Creatine has become one of the most popular dietary supplements among a wide range of healthy and clinical populations. However, its potential adverse effects on kidney health are still a matter of concern. This is a narrative review of the effects of creatine supplementation on kidney function.
View Article and Find Full Text PDFRhabdomyolysis is characterized by muscle damage and leads to acute kidney injury (AKI). Clinical and experimental studies suggest that glycogen synthase kinase 3β (GSK3β) inhibition protects against AKI basically through its critical role in tubular epithelial cell apoptosis, inflammation and fibrosis. Treatment with a single dose of lithium, an inhibitor of GSK3β, accelerated recovery of renal function in cisplatin and ischemic/reperfusion-induced AKI models.
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