Publications by authors named "A C Scholten"
Purpose: Moderate hypofractionation was adopted to reduce hospital visits during the COVID-19 pandemic aiming to maintain treatment efficacy for soft tissue sarcoma (STS) patients, shifting preoperative schedules from 25 fractions of 2 Gy to 14-15 fractions of 3 Gy. This study evaluates the clinical implications and outcomes of this schedule, focusing on wound complications, radiation toxicity, local tumour control, and distant metastases.
Patients And Methods: Data was collected from patients treated between 01 and 01-2020 and 31-12-2023.
Objective: This study aims to assess the long-term safety and efficacy of adding pazopanib to neo-adjuvant radiotherapy followed by surgery in patients with high-risk non-metastatic soft tissue sarcoma of the trunk and extremities treated in the PASART-1 and PASART-2 trials, as well as to compare the PASART cohorts to a control cohort receiving standard treatment during the same time period from the Netherlands Cancer Registry (IKNL) to investigate if adding pazopanib improves Overall Survival (OS).
Methods: Updated follow-up data on disease control, survival and long-term toxicities of the PASART-trials were extracted from electronic patient records. The effect of adding pazopanib to neo-adjuvant radiotherapy on OS was investigated by comparing the combined PASART cohorts to the IKNL cohort via direct comparison and exact matching analysis.
Article Synopsis
- - This study examined how different interpretations of guidelines for outlining left-sided internal mammary lymph nodes (IMN) affect radiation exposure to nearby organs in breast cancer patients.
- - Using a cohort of 95 patients, it compared the NKI's interpretation with a deep learning model based on Danish guidelines, finding significant geometric and dosimetric differences, especially regarding heart dose.
- - The results indicated that variability in guideline interpretations can lead to higher heart radiation doses, highlighting the importance of establishing a uniform consensus in treatment practices to improve patient outcomes.
Background: Radiation associated angiosarcoma (RAAS) of the breast is a rare malignancy with poor survival. Optimal treatment strategies remain uncertain due to a lack of data, and vary between surgery alone and a combination of surgery with (neo)adjuvant chemotherapy (NACT) and/or re-irradiation. The aim of this study was to evaluate the potential benefit of taxane based NACT.
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- * An online survey conducted by the German Society for Public Health Services (DGÖG) gathered input from nearly 500 participants, primarily from local health departments, to prioritize 17 proposed guideline topics across six task areas.
- * All 17 topics were deemed high priority, with a strong emphasis on infection hygiene monitoring, medical expert assessment, and psychosocial emergency care, while additional topics such as health promotion and crisis management were also highlighted for future guideline development.