Femoral neck shaft angle in men with fragility fractures.

Introduction. Femoral neck shaft angle (NSA) has been reported to be an independent predictor of hip fracture risk in men. We aimed to assess the role of NSA in UK men.

Sex steroids and bone turnover markers in men with symptomatic vertebral fractures.

Sex steroids play an important role in the maintenance of bone density in men and women, but the circulating, biologically active unbound fraction is influenced by the concentration of sex hormone binding globulin (SHBG). SHBG increases with advancing age in men and leads to a reduction in serum free testosterone and oestradiol, which may then affect bone turnover, bone mineral density (BMD) and the risk of fractures. We have therefore measured total and unbound sex steroids, SHBG, bone turnover markers and BMD in 57 men with symptomatic low trauma vertebral fractures and 57 age-matched male control subjects.

Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men.

To investigate the pathogenesis and sequelae of symptomatic vertebral fractures (VF) in men, we have performed a case-control study, comparing 91 men with VF (median age 64 years, range 27-79 years) with 91 age-matched control subjects. Medical history, clinical examination and investigations were performed in all patients and control subjects, to identify potential causes of secondary osteoporosis, together with bone mineral density (BMD) measurements. BMD was lower at the lumbar spine and all sites in the hip in patients with VF than in control subjects (p < 0.

The reliability of diagnosing osteoporosis from spinal radiographs.

In order to assess the value of spine radiographs in the diagnosis of osteoporosis, we have measured lumbar-spine bone mineral density (BMD) in 33 women aged 33-74 years whose radiographs were reported as showing 'osteopenia' only and 41 women aged 39-78 with radiological evidence of vertebral deformation. These results were compared with the normal range for young women and with control groups of 41 normal elderly women aged 65-70 and 15 normal younger women aged 50-60. Women with radiological osteopenia had a significantly lower BMD than the younger (p < 0.

Pathogenesis of vertebral crush fractures in women.

In a series of 214 women with vertebral crush fractures, 119 (55.6%) were found to have either an underlying secondary cause of osteoporosis or an early menopause before the age of 45 or both. A secondary cause of osteoporosis was present in 65 women (30.