Publications by authors named "A C Ruiz-Gaitan"
Improving antifungal lipid-based drug delivery against : a review.
Expert Opin Drug Deliv
October 2024
Introduction: Fungal infections, particularly those caused by spp. have increased in recent years. A primary contributor to this surge was the COVID-19 pandemic, where many hospitalized patients had secondary fungal infections.
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- Fungemia poses a significant risk in ICUs, maintaining high mortality rates despite better treatment options, and yeast colonization is a key independent risk factor needing more research.
- In an 8-year study involving 38,017 samples from 3206 patients, researchers investigated colonization patterns, the effectiveness of the Colonisation Index (CI) and Corrected Colonisation Index (CCI), and candidemia risks linked to various yeast species.
- Results indicated increased colonization rates with prolonged hospital stays and highlighted that while yeast colonization has high sensitivity and negative predictive value, its predictive power is relatively low, underscoring the need for weekly surveillance to enhance fungemia risk assessment and antifungal management.
is an emerging, multidrug-resistant yeast that causes systemic infections, mainly in hospitalized or immunosuppressed patients. This pathogen has a high mortality and morbidity rate. This study aims to evaluate the antifungal potential of micafungin (MICA) encapsulated in a nanoemulsion (NEM) against four clades of and other non- species.
View Article and Find Full Text PDFCetaceans, which are crucial in marine ecosystems, act as sentinels for ecosystem and human-environmental health. However, emerging fungal infections, particularly by spp., pose a growing concern in these marine mammals.
View Article and Find Full Text PDFThe species is a multidrug-resistant yeast capable of causing systemic and lethal infections. Its virulence and increase in outbreaks are a global concern, especially in hospitals where outbreaks are more recurrent. In many cases, monotherapy is not effective, and drug combinations are opted for.
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