Publications by authors named "A C Rohwer"
Tranexamic acid for preventing postpartum haemorrhage after caesarean section.
Cochrane Database Syst Rev
November 2024
Rationale: Postpartum haemorrhage (PPH) is common and potentially life-threatening. The antifibrinolytic drug tranexamic acid (TXA) is recommended for treating PPH; it reduces the risk of death from haemorrhage by one-third when given soon after bleeding onset, but not overall risk of death. Interest in whether TXA may be effective in preventing PPH is growing.
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- Spinal muscular atrophy (SMA) is a genetic disorder resulting from mutations in the SMN1 gene, with a study aiming to track changes in motor function over 4 years using the Hammersmith Functional Motor Scale Expanded (HFMSE).
- The research involved analyzing data from multiple countries, focusing on factors like age, functional status, and the number of SMN2 gene copies in SMA types II and III.
- Results showed SMA type II patients had a mean decline of -2.20 points, while type III experienced a -2.75 point decline over 4 years, with age and baseline scores being significant predictors of these changes, suggesting the need for detailed assessment in specific SMA subgroups.
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- Many child health guidelines in Malawi, Nigeria, and South Africa are old and don’t involve enough people in making decisions.
- The GELA project helped create better guidelines by getting groups together to discuss and prioritize the most important child health topics, using current evidence to adapt existing recommendations.
- National teams in these countries created five new recommendations for child health, but they needed more evidence and training to make good decisions.
The Revised upper limb module (RULM) has been increasingly used in clinical trials and in clinical settings. The aim of this study was to use the 'shift analysis' to assess the patterns of lost or gained abilities for each item on the RULM in an untreated cohort, stratified by SMA type, age, SMN2 copy number, and motor functional status. The analysis was performed on 222 12-month paired assessments from 129 individuals (115 assessment from type II and 107 from type III) who had at least two assessments at yearly intervals.
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- The CEBHA+ program offered a course on evidence-based public health in five sub-Saharan African countries to build skills and capacity among individuals and institutions.
- The study used the RE-AIM and PRISM frameworks to assess and learn from the course's implementation, involving reflections and discussions among country teams.
- Results showed that 130 participants improved their EBPH knowledge, faced challenges with hybrid learning formats, and noted the importance of contextualizing content for local public health needs, emphasizing that ongoing funding is crucial for institutionalizing these initiatives.