Publications by authors named "A C Quayle"

Bacterial vaginosis (BV), a dysbiosis of the vaginal microbiota, is a common coinfection with (Ct), and BV-associated bacteria (BVAB) and their products have been implicated in aiding Ct evade natural immunity. Here, we determined if a non-optimal vaginal microbiota was associated with a higher genital Ct burden and if metronidazole, a standard treatment for BV, would reduce Ct burden or aid in natural clearance of Ct infection. Cervicovaginal samples were collected from women at enrollment and, if testing positive for Ct infection, at a follow-up visit approximately one week later.

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Bacterial vaginosis (BV) is the most common vaginal dysbiosis. In this condition, a polymicrobial biofilm develops on vaginal epithelial cells. Accurately quantifying the bacterial burden of the BV biofilm is necessary to further our understanding of BV pathogenesis.

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Article Synopsis
  • - This pilot study aimed to explore the changes in vaginal microbial communities in African American women before the onset of incident bacterial vaginosis (iBV) using advanced shotgun metagenomic sequencing methods.
  • - Results showed that certain bacteria associated with BV, like G. vaginalis and Fannyhessea vaginae, increased significantly, while beneficial Lactobacillus species decreased leading up to iBV.
  • - The study highlights critical bacterial dynamics and potential mechanisms involved in the development of iBV, contributing to the understanding of this common condition.
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Research has highlighted the importance of Indigenous knowledge and cultural practice in healing from ongoing histories of trauma, dispossession, and displacement for Indigenous peoples in Australia and elsewhere. Connection with culture, Country, and kinship has been identified as protective factors for Aboriginal social and emotional well-being and as facilitating cultural healing. This paper draws on stories mediated through cultural practice specifically, Wayapa and bush-dyeing workshops, to explore how women resignified experiences and engaged in "healing work.

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