Publications by authors named "A C Puller"
Superficial fibromas are a group of mesenchymal spindle cell lesions with pathomorphological heterogeneity and diverse molecular backgrounds. In part, they may be indicators of an underlying syndrome. Among the best-known entities of superficial fibromas is Gardner fibroma, a plaque-like benign tumor, which is associated with APC germline mutations and occurs in patients with familial adenomatosis polyposis (Gardner syndrome).
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- Transgenesis is a key genetic technique, and the use of Tol2-based systems with Gateway vectors has improved zebrafish transgenesis, making it easier to use.
- The authors developed new tools for testing gene regulatory elements and expanded the color options for transgenic research by introducing vectors with various fluorophores.
- They also created specific transgenesis markers for the zebrafish pineal gland that work before and after hatching, which can be applied to other species like cavefish, enhancing the versatility of their transgenic applications.
Article Synopsis
- Aberrant levels of the transcriptional modulator ZNF423 are linked to the development of B-cell leukemia, specifically investigating its role in various acute lymphoblastic leukemia (ALL) subtypes using data from 1354 samples.
- Analysis of a pro-B ALL model using CRISPR-Cas9 showed that removing ZNF423 led to decreased cell viability and improved survival in mice, highlighting its importance in leukemia progression.
- The study uncovered a complex relationship where ZNF423 binds to EBF1 target sites, repressing gene activity and disrupting EBF1's functions, which contributes to altered transcriptional regulation and influences B-cell development and leukemogenesis.
Article Synopsis
- The study highlights the role of the Microphthalmia-associated transcription factor (MITF) in regulating DNA repair and transcription in melanocytic cells, which are sensitive to UV radiation.
- MITF activates the transcription factor GTF2H1, enhancing nucleotide excision repair and ensuring timely resumption of transcription, crucial for the survival of melanocytes and melanoma cells.
- Additionally, MITF influences c-MYC to regulate general transcription and CDK7, suggesting a novel mechanism that could be targeted for therapeutic interventions in melanoma.