Distribution of amiodarone in heart tissues following intrapericardial administration.

The distribution of amiodarone (A) in heart tissues of open chest anesthetized animals was studied at 20 and 60 min following the insertion of an isotonic solution of the drug into the pericardial sac (PS) in doses from 0.25 to 3 mg per kg body weight (BW) for pigs and after 60 min in doses of 3 to 6 mg for dogs. Most of the A absorbed by the myocardium was found in the subepicardium part of the left ventricular (LV) wall.

Rapid diminution of calcium in the myocardium by transfer to pericardial solutions. Myocardial dialysis.

A new method is described for the controlled and specific depletion of calcium from the vascularly perfused heart of experimental animals by means of dialysis, using a pericardial solution. A 30-40 ml isotonic phosphate buffer pH 7.3 with a low Ca2+ and high Mg2+ concentration (0.

Distribution of lidocaine and digoxin in heart tissues and aorta following intrapericardial administration.

The distribution of lidocaine and digoxin in myocardial and aorta tissues of open chest anesthetized dogs was studied, following the administration of 30 ml phosphate buffer solution of the drugs in the pericardial cavity where it was kept for increasing time intervals. Transfer of lidocaine (15 or 30 mg) from the solution to myocardium was almost complete within 60 min, while only 50% of digoxin (2 or 50 micrograms) was removed, and this occurred during the first 30 min. Accordingly, the absorption rate of lidocaine by heart tissues increased with time up to 60 min while that of digoxin decreased with time.

Effect of low calcium on high-energy phosphates and sarcolemmal Na+/K(+)-ATPase in the infarcted-reperfused heart.

This study was undertaken to compare the effect of low to normal serum calcium on biochemical parameters in the myocardium of dogs subjected to 90 min of coronary artery ligation followed by 30 min reperfusion. The accumulation of calcium, the decrease of adenosine triphosphate (ATP) and creatine phosphate (CP) and the inhibition of sarcolemmal ouabain-sensitive Na+/K(+)-ATPase which are prominent findings in the ischemic-reperfused myocardium, were studied under normal and low serum Ca produced by normal and modified hemodialysis (HD). The results showed a lower accumulation of Ca (P less than 0.