Publications by authors named "A C Pignatari"
Article Synopsis
- * This study focuses on three multidrug-resistant (MDR) bacterial isolates found in the stool samples of swine and bovine in Brazil, all belonging to the same clone and carrying various antimicrobial resistance genes (ARGs).
- * Whole genome sequencing of one isolate revealed resistance to several types of antibiotics and highlighted genetic similarities with bacteria found in animals and humans in the USA and Malaysia, indicating a concerning spread of antibiotic-resistant pathogens in the food supply.
Article Synopsis
- The study investigates a New Delhi Metallo-β-lactamase (NDM)-1-producing Klebsiella quasipneumoniae subsp. quasipneumoniae (KQPN) strain found in Brazil, addressing a gap in whole genome sequencing data for Enterobacterales in the region.
- Whole genome sequencing was performed on the isolated strain (A-73.113) to analyze its antimicrobial susceptibility and genetic features, identifying resistance to several antibiotics and the presence of various virulence and plasmid-encoding genes.
- The findings contribute to the understanding of antimicrobial resistance and the genetic makeup of this clinically significant strain, emphasizing the need for ongoing surveillance.
Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022.
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- The study challenges the idea that plasmids carrying virulence and antibiotic resistance genes impose a fitness cost on bacteria, showing minimal impact on bacterial growth after acquisition.
- Plasmids from specific Shiga toxin-producing E. coli strains were transferred to non-virulent E. coli strains, revealing that the biological cost of carrying these plasmids was low or negligible.
- These findings imply that there are fewer evolutionary barriers to the dissemination of these plasmids among bacteria than previously thought, potentially facilitating the spread of traits associated with virulence and resistance.
Carbapenem-resistant Klebsiella pneumoniae bloodstream infections in haematological malignances and hematopoietic stem cell transplantation: Clinical impact of combination therapy in a 10-year Brazilian cohort.
Ingvar Ludwig Augusto de Souza Paola Cappellano Diogo Boldim Ferreira Maria Daniela Bergamasco Thomas Cardoso das Chagas Neto Antonio Carlos Campos Pignatari
PLoS One
January 2024
Article Synopsis
- Bacterial bloodstream infections (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (CRKp) are prevalent in patients with hematological malignancies and stem cell transplant recipients.
- A study of 65 BSI episodes over 10 years identified acute leukemias as the most common underlying condition and highlighted mucosal barrier injury in the gastrointestinal tract as the primary cause of infection.
- The research found that timely and appropriate antibiotic treatment significantly improved survival rates, while factors like hypotension at presentation and concurrent invasive fungal diseases were linked to higher 30-day mortality.