Frequency and characteristics of circulating CD4(+) CD28(null) T cells in patients with psoriasis.

Background: Psoriasis is a chronic inflammatory disease that affects the skin. CD4(+) CD28(null) cells are a subset of T lymphocytes associated with systemic inflammation and increased cardiovascular disease risk, and may be involved in the pathogenesis of psoriasis.

Objectives: To study the features of circulating CD4(+) CD28(null) cells in patients with psoriasis, adjusted for the influence of known cardiovascular disease risk factors.

Focal prostatic atrophy: morphologic classification and immunohistochemistry.

Objective: To describe the morphology of focal prostatic atrophy and propose a comprehensive histologic classification for a proper diagnostic recognition.

Study Design: A broad immunohistochemical study was performed as an adjunct to its recognition as well as a contribution to pathogenesis.

Results: A morphologic continuum was seen on needle biopsies.