Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats.

This study was designed to characterize the effects of low doses (0.5-5 ng) of pro-inflammatory cytokines, interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor (TNF), on the neural activity of dorsal root ganglion (DRG) in rats. The purpose of this study was to examine the effects of cytokines (IL-1beta, IL-6, and TNF) on the somatosensory neural response of DRG.

The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge.

This study investigated cytokine expression, behavioral and neurophysiologic changes in Lewis rats whose lumbar nerve roots were exposed to nucleus pulposus (NP). Allografted NP or fat was implanted over the left L5 nerve root. Sham rats had no NP or fat implantation.

The effect of varying impact energy on diffuse axonal injury in the rat brain: a preliminary study.

Diffuse axonal injury (DAI) is seen as widespread damage in the white matter of brain characterized by morphological changes to axons throughout the brain and brain stem. The current study attempted to investigate the effect of increasing impact energy on the presence and severity of DAI in corpus callosum (CC). DAI was induced in adult male Sprague-Dawley rats using an injury model adapted from Marmarou et al.

Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in rats.

The release of inflammatory cytokines caused by a disrupted disc may play a critical role in pain production at nerve endings, axons, and nerve cell bodies. Herniated disc tissue has been shown to release inflammatory cytokines such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor (TNF), and other algesic chemicals. This study was designed to characterize the effects of these proinflammatory cytokines on the somatosensory neural response at the dorsal root level in rats.

Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion.

Study Design: This study was designed to characterize the effects of phospholipase A2 on the neural response of dorsal root and dorsal root ganglion in the anesthetized New Zealand White rabbit.

Objectives: To examine the effects of phospholipase A2 on the neural response of somatosensory neurons at the dorsal root ganglion level.

Summary Of Background Data: Phospholipase A2 may be an irritating component of disc tissue that is present in high concentration in painful herniated discs, in synovial fluids, and in sera of rheumatoid arthritis patients.