Publications by authors named "A C Muller Kobold"
Article Synopsis
- The study aimed to evaluate plasma procalcitonin and urine biomarkers (IL-8, NGAL, calprotectin) for diagnosing urinary tract infections (UTIs) in the emergency department.
- While 46.4% of patients were clinically diagnosed with UTIs, procalcitonin was ineffective as a diagnostic tool, and the urine biomarkers showed elevated levels but had low specificity and only moderate accuracy compared to routine tests.
- The urine biomarkers mainly indicated the presence of white blood cells in urine (leukocyturia) rather than providing significant additional diagnostic value, except for a slight advantage in patients with low white blood cell counts.
Background: Knee osteoarthritis (KOA) presents a prevalent orthopedic condition causing substantial impairment in the quality of life and imposing a significant societal and economic burden. Mesenchymal stromal/stem cells (MSCs), known for their regenerative properties and immunomodulatory effects, have emerged as a promising therapeutic avenue in regenerative medicine. Despite MSCs' therapeutic potential, their precise mechanisms of action in KOA remain underexplored.
View Article and Find Full Text PDFIntroduction: Bone turnover markers (BTM) are biochemical compounds reflecting different stages of bone metabolism. Their levels change with age and differ between males and females. This makes clinical interpretation and comparison more difficult.
View Article and Find Full Text PDFBackground: Obesity is a risk factor for adverse outcomes in COVID-19, potentially driven by chronic inflammatory state due to dysregulated secretion of adipokines and cytokines. We investigated the association between plasma adipokines and COVID-19 severity, systemic inflammation, clinical parameters, and outcome of COVID-19 patients.
Methods: In this multi-centre prospective cross-sectional study, we collected blood samples and clinical data from COVID-19 patients.
Background: Measurement of the 24-h urinary iodine concentration or urinary iodine excretion (UIE) is the gold standard to determine iodine status; however, this method is inconvenient. The use of salivary iodine could be a possible alternative since salivary glands express the sodium-iodine symporter.
Objectives: We aimed to establish the correlation between the salivary iodine secretion and UIE, to evaluate the clinical applicability of the iodine saliva measurement.