Publications by authors named "A C Moorman"
As cancers progress, they become increasingly aggressive-metastatic tumours are less responsive to first-line therapies than primary tumours, they acquire resistance to successive therapies and eventually cause death. Mutations are largely conserved between primary and metastatic tumours from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression and therapy resistance. However, we lack an understanding of metastatic cell states and the mechanisms by which they transition.
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- The study explores how the mammalian brain develops through the transformation of the cranial neural plate into a closed tube essential for neural structure and function.
- Single-cell RNA sequencing was employed to create a detailed gene expression map during various stages of cranial neural tube closure in mouse embryos, successfully predicting spatial gene expression patterns.
- The findings highlight the role of Sonic hedgehog (SHH) signaling in shaping different regions of the brain, revealing complex interactions between various developmental signaling pathways.
Objective: The objective of this prospective observational research project was to have dairy producers use and assess the utility of a cull cow evaluation form.
Animals: Cull dairy cows.
Procedure: Veterinarians were recruited to enrol a purposively selected group of dairy producers into a project to evaluate a cull cow evaluation form.