Unipolar Mania: Prevalence and Patient Characteristics.

Objectives: Recurrent [hypo]mania without major depressive episodes ("unipolar mania" [UPM]) is an uncommon form of major affective disorder related to bipolar disorder (BD). We characterized UPM patients and estimated the prevalence of their characteristics based on prolonged times-at-risk.

Methods: Using standard bivariate and multivariate statistics, we compared the characteristics of 63 consecutive UPM patients to 1210 other BD patients over prolonged, close, prospective follow-up at expert mood disorder centers.

Atypical depression and emotion dysregulation: Clinical and psychopathological features.

Background: Most atypical depression (AD) cases endorse prominent mood reactivity, anxiety, and interpersonal sensitivity, resembling some of the characteristics of emotional dysregulation (ED). The present study assesses the frequency and clinical features of different levels of ED in AD vs. non-AD(AD) cases.

Techniques for randomization and allocation for clinical trials.

Intervention studies require all participants to originate from the same population, with random allocation to intervention groups to ensure comparability. Randomization is crucial for minimizing confounding factors, allowing differences in outcomes to be attributed to the intervention. Simple randomization performs well for large samples (>100 per group), but smaller samples may require block or stratified randomization to balance group sizes and covariates.

Affective temperaments: Effects on treatment response for major depression.

There is growing interest in assessing affective temperaments in relation to major depressive disorder (MDD) and bipolar disorder (BD). Needed is evaluation of the impact of temperament ratings on responses to treatment of depression in these disorders. We measured treatment response as %-improvement in HDRS depression ratings and correlated this measure as well as response rate (≥50 % improvement) with TEMPS-A ratings of anxious, cyclothymic, dysthymic, hyperthymic, and irritable affective temperaments in 2264 mood-disorder patients (1165 BD, 1099 MDD; 62.

Efficacy and tolerability of 1.6% phenol-croton peeling versus topical 5% imiquimod in the treatment of actinic cheilitis: a randomized clinical trial.

Background: Trials evaluating the effectiveness of topical treatments for actinic cheilitis (AC) are scarce. Despite no comparative data, phenol-croton peeling has been reported as effective in treating this condition.

Methods: An open, randomized trial was conducted to compare the effectiveness and tolerability of 1.