Publications by authors named "A C Mbakwem"
Article Synopsis
- Nigeria has the highest global rate of peripartum cardiomyopathy, leading to a clinical trial that compared usual care with AI-guided screening for left ventricular systolic dysfunction (LVSD) in pregnant and postpartum women.
- The study involved 1,232 women, using digital stethoscopes and 12-lead electrocardiograms to identify LVSD, which was confirmed by echocardiography.
- Results showed that AI screening enhanced the detection rates of LVSD (4.1% vs. 2.0% for stethoscope AI; 3.4% vs. 2.0% for electrocardiogram AI), with no serious adverse events reported during the trial.
Background And Aims: INTERASPIRE is an international study of coronary heart disease (CHD) patients, designed to measure if guideline standards for secondary prevention and cardiac rehabilitation are being achieved in a timely manner.
Methods: Between 2020 and 2023, adults hospitalized in the preceding 6-24 months with incident or recurrent CHD were sampled in 14 countries from all 6 World Health Organization regions and invited for a standardized interview and examination. Direct age and sex standardization was used for country-level prevalence estimation.
Article Synopsis
- * Even those who recover may deal with long-term health issues like hypertension and arrhythmias, affecting not just their health but also their families' well-being and quality of life.
- * A collaborative, multidisciplinary approach is essential for managing PPCM, involving various healthcare professionals to address both medical and psychosocial needs, along with informing women about the risks of future pregnancies.
Cardiovascular toxicities of immune therapies for cancer - a scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology.
Eur J Heart Fail
October 2024
Article Synopsis
- Immunological therapies, including immune checkpoint inhibitors (ICIs) and cell-based therapies like CAR-T, have transformed cancer treatment by enabling the immune system to target cancer cells.
- While these therapies are generally effective, they can cause immune-related adverse events (irAEs) that vary in severity and timing, from mild skin rashes to serious complications such as myocarditis or cytokine release syndrome.
- The statement discusses the growing understanding of cardiovascular toxicities associated with these therapies, outlines their diagnosis and management, and identifies gaps in current research that need further exploration.
Background And Aims: Hypertension is an independent risk factor for cardiovascular complications. The effect of systemic hypertension on the right ventricle (RV) has received less attention probably due to its complex structure and location. The aim of the study was to assess the effect of systemic hypertension on the structure and function of the right ventricle using transthoracic echocardiography.
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