Publications by authors named "A C Manjunath"
Background: Orthotopic Heart transplantation (OHT) is a definitive treatment for patients with advanced heart failure. Despite available evidence, recipients and some clinicians remain hesitant to accept organs from Increased Risk Donors (IRD). This study aims to report trends in acceptance of donors from IRD donors and long-term outcomes.
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- ADARs are RNA editing enzymes that convert adenosine to inosine in double-stranded RNA, allowing for potential correction of mutations using guiding oligonucleotides.
- Their editing efficiency is affected by the presence of specific nucleotides near the target adenosine, with substrates adjacent to guanosine being less efficiently edited.
- This study explores modified oligonucleotides that enhance editing at problematic 5'-GA sites, showing that certain analogs improve editing and elucidating how structural changes facilitate this process.
Article Synopsis
- - The study analyzed ACL injuries in NBA players from the 2009-2010 to 2019-2020 seasons, focusing on mechanisms, body positions, and activities during injury using video analysis and a detailed survey.
- - Results showed that most ACL injuries occurred during offensive play, primarily through indirect contact while pivoting or dribbling, with no injuries resulting from direct knee contact.
- - Common knee positions at the time of injury included early flexion and abduction, while foot positions often involved abduction, eversion, and dorsiflexion, highlighting specific biomechanical factors at play in these injuries.
Clinical outcomes of total joint arthroplasty in patients with bowel ostomies.
Arch Orthop Trauma Surg
August 2024
Introduction: The influence of prior colostomy or ileostomy on patients undergoing joint arthroplasty remains poorly understood. Our study aimed to assess whether patients with an ostomy undergoing hip and knee arthroplasties have worse postoperative outcomes and increased rates of revisions.
Method: A single-center, retrospective review of patients with a history of bowel ostomy who underwent a primary total hip arthroplasty (THA), hemiarthroplasty (HA), and total knee arthroplasty (TKA) from 2012 to 2021.
Mid-term outcomes of total hip arthroplasty in patients younger than 30 years.
Arch Orthop Trauma Surg
August 2024
Introduction: Total hip arthroplasty (THA) has predominantly been utilized to treat older patients with primary osteoarthritis. However, recent improvements in surgical technique and implant materials have increased implant longevity, making THA a viable option for younger patients (< 30 years old). While trend analyses indicate an expanding utilization of THA in younger patients with non-OA diagnoses, current data on mid- and long-term THA outcomes in this population are limited.
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