Publications by authors named "A C Maddocks"
Objective: Fetal head and neck masses can result in critical airway obstruction. Our study aimed to evaluate prenatal factors associated with the decision for a definitive airway, including ex-utero intrapartum treatment (EXIT), at birth among at-risk fetuses.
Methods: A single-institution retrospective review evaluated all fetal head and neck masses prenatally diagnosed from 2005 to 2023.
Article Synopsis
- Pediatric brain and spinal cord tumors are a significant health concern, being the second most common cancer in children, and current imaging methods have long acquisition times that hinder timely diagnosis.
- This study explores the use of tailored magnetic resonance fingerprinting (TMRF) to quickly produce both quantitative relaxometric maps and qualitative images in pediatric patients with brain tumors.
- Results showed significant differences in tissue types and a strong correlation between TMRF images and standard imaging methods, suggesting TMRF could streamline imaging protocols while saving time.
Approach to New-Onset Psychosis in Pediatrics: A Review of Current Practice and an Interdisciplinary Consensus-Driven Clinical Pathway at a Single-Center Institution.
J Child Neurol
March 2023
New-onset psychosis in the pediatric population poses many diagnostic challenges. Given the diversity of underlying causes, which fall under the purview of multiple medical specialties, a timely, targeted, yet thorough workup requires a systematic and coordinated approach. A committee of expert pediatric physicians from the divisions of emergency medicine, psychiatry, neurology, hospitalist medicine, and radiology convened to create and implement a novel clinical pathway and approach to the pediatric patient presenting with new-onset psychosis.
View Article and Find Full Text PDFNeural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are associated with intellectual disability, but the pathogenic mechanism remains obscure. Here, we characterize 31 individuals with de novo missense variants in CERT1.
View Article and Find Full Text PDFArticle Synopsis
- Congenital lung malformations (CLM) are rare fetal lung issues that usually go unnoticed until birth, but recent advances like fetal MRI can help better assess these conditions alongside traditional ultrasound.
- A study involving 111 patients from 2006-2020 aimed to find links between prenatal imaging indicators (like cyst size and lung volume ratios) and postnatal respiratory problems, revealing that larger cyst volumes were significantly associated with the need for mechanical ventilation and urgent surgery.
- The findings suggest that while ultrasound parameters are useful for predicting respiratory issues after birth, other factors such as maternal health conditions may also play a role, and not all imaging indicators were found to correlate with patient outcomes.