Publications by authors named "A C M G Miguel"

We have read with great interest the recent review published by Dr. Ebo and collaborators on cannabis allergy. It highlights the difficulties in getting a valid diagnosis because some patients do not admit its consumption, which may not be legalized, there are no commercial extracts and there are problems in cutaneous tests interpretation due to cross-reactivity with other related allergens.

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For several years, our society has been experiencing an aging of the population. Concurrently, there has been an observable increase in the population of nursing homes (EHPAD). The context of a global epidemic and the public health measures implemented to address it have underscored the vulnerability of our elderly population and the need for remote consultations to ensure continuity of care.

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Dry eye syndrome is a multifactorial disease with a complex pathophysiology. The associated morbidity is a worldwide public health problem. The development of autologous serum-based eye drops is an interesting treatment but presents some constraints.

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Despite the central role attributed to neuroinflammation in the etiology and pathobiology of Alzheimer's disease (AD), the direct link between levels of inflammatory mediators in blood and cerebrospinal fluid (CSF) compartments, as well as their potential implications for AD diagnosis and progression, remains inconclusive. Moreover, there is debate on whether inflammation has a protective or detrimental effect on disease onset and progression. Indeed, distinct immunological mechanisms may govern protective and damaging effects at early and late stages, respectively.

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Article Synopsis
  • Limited research exists on dementia publications from Latin America, particularly Brazil, which has been identified as an underrepresented area in scholarly work.
  • A comprehensive literature search covering 2010-2021 revealed 2,528 relevant Brazilian publications on dementia, with a significant focus on diagnosis and disease mechanisms.
  • The majority of these works came from Southeast Brazil, predominantly São Paulo, with a noticeable gender disparity in authorship roles, and a call for increased studies in epidemiology and economic aspects of dementia across all regions of the country.
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