Publications by authors named "A C Luque-Badillo"
Article Synopsis
- Bladder cancer primarily impacts men with higher rates of incidence and mortality, highlighting the need for better predictive models in treatment.
- This study presents a novel 3D in vitro tumor model using decellularized pig bladders, which effectively replicates the tumor microenvironment and overcomes limitations of traditional 2D cultures.
- The model demonstrated efficacy in drug screening with significant predictive reliability (83.3%) for treatment responses, outperforming conventional 2D systems.
Article Synopsis
- This study addresses the ongoing kidney shortage for transplantation in patients with end-stage renal disease (ESRD) by exploring tissue engineering as a potential solution.
- Researchers used pig kidneys, which are similar to human kidneys, and removed their cells through a process called decellularization to retain their structure.
- By infusing pig kidney cells and human red blood cells into these decellularized kidneys, the study shows promising results that could lead to increasing the availability of transplantable organs for ESRD patients.
Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a complex interplay of various immune cells, cytokines, and signaling pathways. One of the critical features of the ccRCC TIME is the presence of infiltrating immune cells, including T cells, B cells, natural killer cells, dendritic cells, and myeloid-derived suppressor cells.
View Article and Find Full Text PDFIn the present study, the inhibitory effect of chlorogenic acid (CGA), a phenolic compound with potential antitumor effects, on circulating microRNA 31 (miR-31), was evaluated in RKO colon cancer cells. The capacity of gold nanoparticles (AuNPs) to enhance miR-31 quantification after treatment with CGA was assessed. RKO cells were treated with different concentrations of CGA for 24, 48 and 72 h, after which AuNPs coupled to CD81 were added to the supernatants.
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