The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation.

Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation-a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII) and XI (FXI), prekallikrein (PK), and high molecular weight kininogen interact with anionic surfaces-has been shown to be activated in Gram-negative septic patients.

The projected impacts of climate change and fishing pressure on a tropical marine food web.

Small-scale fisheries, especially those from developing countries, are vital for millions. Understanding the impact of environmental and human factors on fish stocks and yields and how they might change is crucial to ensure the sustainable use of aquatic resources. We developed an ecosystem model using Ecopath and Ecosim (EwE) to investigate changes in target species biomass and ecosystem attributes over 83 years (2017-2100) caused by different scenarios of fishing pressure and ocean warming in the Brazilian Northeastern continental shelf.

The role of intraspecific mechanical and chemical signaling for mate and sexual recognition in male Tityus pusillus (Scorpiones, Buthidae).

Hydrophobic compounds present in the cuticular wax layer (CWL) of terrestrial arthropods protect them from dehydration and are also involved in chemical communication. However, the role of CWL compounds in the behavioral ecology of scorpions has been studied less often, with most investigations focusing on their responses to mechanical stimuli. In this study, we aimed to characterize the CWL composition of Tityus pusillus (Scorpiones, Buthidae) and examine the influence of CWL solvent extracts and movement on intraspecific mate and sexual recognition by males of this species.

Ineffective overweight self-management: A study of diagnostic accuracy and etiological relationships.

Purpose: To evaluate the accuracy of clinical indicators and etiological factors associated with the nursing diagnosis of ineffective overweight self-management among university students.

Method: A diagnostic accuracy study with a cross-sectional design was conducted with 108 university students. A latent class analysis model with random effects was used to establish sensitivity and specificity measures of clinical indicators, estimate the prevalence of the diagnosis, and calculate posterior probabilities for the diagnosis.

Empirical Testing of a Middle-Range Theory for Ineffective Breathing Pattern in Children With Congenital Heart Disease.

Aim: To test a middle-range theory (MRT) for the nursing diagnosis of ineffective breathing pattern in children with congenital heart disease (CHD) based on analysis of two general propositions.

Methods: This cross-sectional study is guided by STROBE. The propositions represent hypotheses about the relationships between the concepts of this MRT to be tested empirically, and thus, log-linear models were used to verify the structure of the proposition related to the stimuli.