Publications by authors named "A C Laursen"
Background: Epidemiologic studies have demonstrated that ambient concentrations of particulate matter < 2.5 μm (PM) are associated with reduced fecundability, the per cycle probability of conception. The specific constituents driving this association are unknown.
View Article and Find Full Text PDFStudy Question: To what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)?
Summary Answer: Preconception levels of vigorous, moderate, or total PA were not consistently associated with fecundability across Danish and North American cohorts, but there was suggestive evidence that bicycling with a 'soft, comfort seat' was associated with reduced fecundability in both cohorts, especially among males with greater BMI.
What Is Known Already: Among males, some studies indicate that moderate PA might improve fertility, whereas vigorous PA, especially bicycling, might be detrimental.
Study Design, Size, Duration: We assessed the association between male PA and fecundability among couples participating in two preconception cohort studies: SnartForaeldre.
Article Synopsis
- Anifrolumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE) but comes with a heightened risk of viral infections, notably herpes zoster (HZ), with reported rates of 6.1% in clinical trials.
- In two unique cases, SLE patients on anifrolumab experienced severe herpesvirus infections—disseminated HSV-2 and HZ encephalitis—marking a concerning new trend not previously documented.
- The findings underline the importance of assessing patients' viral infection history and recommending vaccinations, like the recombinant zoster vaccine, before starting anifrolumab therapy to mitigate infection risks.
Background: The use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools.
Objective: To investigate the association between fertility indicators and fecundability in Danish women trying to conceive.
Methods: Web-based preconception cohort study.